Researchers from Pritzker Molecular Engineering, under the guidance of Prof. Jeffrey Hubbell, demonstrated that their compound can eliminate the autoimmune response linked to multiple sclerosis. Researchers at the University of Chicago’s Pritzker School of Molecular Engineering (PME) have developed
Psoriasis? Plz.
Yeah, pretty please.
Psoriatic arthritis recently manifested itself after just struggling with psoriatic nails and a little on my scalp. I’m only 33 and in the mornings I have absolutely 0 fine motor skills and it’s difficult to do things like unlock my front door when I leave for work. Painful as well. My dermatologist referred me to a rheumatologist….1 year for an appointment. No joke.
I hope you get help soon!
I had large amount of psoriasis spots on my arms and legs and also developed arthritis and for me Humira helped immensely.
No more pain and spots.
I cannot WAIT to get put on something like that. Happy you’re doing well.
My psoriasis went away completely after getting rid of/managing my mast cell activation syndrome, which was in turn caused by compression of the bottom of my spine
Some food for thought
Can you elaborate?
About what part?
What happened in your spine, how did you detect it?
There seems to be some compression in or around the cauda equina, I found out by pure fluke. I noticed I got a lot worse with the MCAS after doing hip thrusts with weights and after anything else that bends the lower back. Decided to hold my lower back really rigidly straight for a few days and my health issues were practically gone, and have been since.
There seems to be a few case reports online of people with MCAS getting a full cure after spinal decompression surgery but I think they had tethered cord syndrome.
Not sure what the best long term solution will be, need to find out why those nerves get crushed when bending but scans thus far are inconclusive
This honestly sounds like what I’ve been experiencing for months and my Dr can’t figure it out, the leading guess right now is long covid. I noticed on the Wikipedia page it even mentions long covid, are they similar? Does your lymph node randomly swell up?
Long covid is very similar to MCAS
Yeah lymph nodes in my head would randomly feel swollen
I just got slapped with an auto immune problem with my thyroid. It’s inflamed and will never go back to normal. So far I only have a fat neck and I’m stable but at any moment I might develop hypothyroidism because of this. I can’t wait for this to work.
Edit: having said that… the source of this post has been known for clickbait bullshit articles so maybe I shouldn’t hold my breath :(
Hypo here since just a couple years. I just take Eutirox daily and monitor my TSH levels each year. Other than that it’s been fine, no quality of life issues for me luckily yet
Great to hear!
I’m not even there yet, just have an inflamed thyroid, but really not much I can do about it
Take hyperthyroidism seriously. Left untreated it will change your personality and those changes will be permanent even after you kill your thyroid.
So far my levels are okay and I’ll have to do half yearly checkups to catch it changing. But from what I’m seeing it’s mostly an incrrased risk, not a death sentence just yet
That’s good 😊. My ex wife had graves. She is a women and has always been heavy so Dr’s ignores the symptoms for nearly a decade.
Yeah that sucks. Really shows its a tug of war between doctors and patients, where patients get to deal with doctors that don’t care / have prejudices that cause misdiagnoses, while doctors have to deal with patients who think they know better than the doctor… I’m happy that for the moment I’m fine
The source of this post might be. But the study is solid as far as I can see. It was published in Nature Biomedical Engineering last week.
https://www.nature.com/articles/s41551-023-01086-2
As phase I clinical trials are underway, we’ll see how far this can get. But sure, don’t expect too much, then you won’t be disappointed. Let’s hope it can really help people.
Thanks for that link. I trust nature.com quite a bit more
It seems like a decently written article… certainly more readable than the abstract of the scientific article.
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Notably they trialled first for coeliac autoimmune, but it’ll be 2024 before phase 2 results are out for that. About 10 years back there was a similar vaccine which also passed phase 1 trials but failed at phase 2. Phase 1 is basically testing that the vaccine does no harm in small groups and it is phase 2 where they measure if it is actually efficacious and to what level. If it passes phase 2, then get your hopes up.
I work in clinical (and preclinical) trials. And I have celiac disease. I’m hopeful but not optimistic that I’ll be able to eat pasta within the next decade.
Reverse Type 1 Diabetes
Didn’t even read past that lie.
Just 5 more years!
???
False hope is a terrible thing. Are there any lemmy communities with enforced certainty thresholds on his sort of article? Would be nice to be able to trust headlines somewhere.
Then you’re dumb, honestly.
I love these people that act like it’s 1812 and great leaps in medicine are impossible.
Yeah, sure 🙄
I have MS, I’ll go wild once I hear it’s approved. Until then I’ll save my energy.
I will click on this headline when the link is to Nature or Scientific American or the Mayo Clinic. Thank you very much.
The article has the link to the original paper published in Nature Biomedical engineering at the bottom.
Thanks!
Hm, well the full paper is behind a subscription wall but the abstract sounds much more modest:
Our findings show that pGal–antigen therapy invokes mechanisms of immune tolerance to resolve antigen-specific inflammatory T-cell responses and suggest that the therapy may be applicable across autoimmune diseases.
“May be applicable” —> “can completely reverse” ???
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It’s tough to see promising treatments and cures for Type 1. There have been huge inroads for treatment but a cure always seems just around the corner. Here’s to hope for all the Type 1’s and thank you for all the people looking to find that cure.
Lol, just around the corner is right. My doctor, waaaay back in the 90s, said a cure was 10-15 years away. I think it’s just language they use. Especially when they are talking to the extremely sick/depressed who just learned what they have.
It usually is that close, but that’s assuming unlimited funding… Imagine if anything else had the funding that COVID did.
My wife has MS. And even though we are of course far from being at a point where the disease will be cured, articles like this give hope.
There are a lot of smart people who are dealing with the topic. Hopefully they can get something solid done soon!
MS, ALS, and Alzheimer’s are probably the diseases I hope they cure the most at some point. Those 3 are just so ruthless and so hard on everyone. Every time I see something like this I’m super excited but I also feel like I’ve been hearing stuff like this for decades now
I wonder what the implications for transplant recipients are.
That’s the holy grail for this type of research. Autoimmune cures are seen as a stepping stone for that
Let’s not put the cart before the horse.
… But also I’d like to point out that celiac is an autoimmune disease, so for some people this may be a vaccine against gluten free bread.
so for some people this may be a vaccine against gluten free bread
The most marvelous medicine in the history of humanity.
… initial phase I safety trials have already been carried out in people with celiac disease …
Not being snarky, just relating the article to your statement.
My son (who is 9) was diagnosed with celiac when he didn’t grow from age 2-3 (gluten -> guts make enzyme to digest it -> immune system sees enzyme making cells as invaders -> immune system attacks cells -> intestines swell -> nutrition stops being absorbed). He was effectively starving despite eating. He’s on track now as we have a strict gluten free household, and the fad people have created a market demand which makes companies want to make products that give him options…but a treatment like this would be life changing.
The good thing for him is that he was so young when he was diagnosed that he probably doesn’t know anything else. Saying this from personal experience as I was diagnosed at 14 months in mid 80s. Of course, something like this would be amazing as I can’t tolerate even small amounts of accidental gluten but as I don’t know anything else I can’t even imagine anything else.
Aye, the difference between me, diagnosed in preteens, and my friend, diagnosed at 3, is immense. I still have the odd craving and sometimes indulge with stupid results. She? Never even crosses her mind.
The research is interesting, but I don’t appreciate the bullshit clickbait headline.
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Honestly, this is a fair response to an outrageously sensationalist headline. There is promise in this particular style of vaccine, and it deserves further research, but to claim it’s going to cure all these disorders is something so far from the current truth that it really verges on an outright lie.
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Yours being in the negative is the whole reason I responded to it, actually. I was hoping my context could make people see that yours was the appropriate stance for those who aren’t hopelessly naive. Sorry it didn’t work!
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Because there’s a difference between “dismissive” and “skeptical.” Your comment was dismissive whereas adj16’s was skeptical.
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And surprise surprise, when actual sentences are used to express full ideas and sentiments instead of just sarcasm, it gets accepted better, especially when it’s something that actually matters to folks.
Negative output = negative responses
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Ok bro
They added subtlety and made a point, you just reacted skeptically to a headline
If you’re surprised by this, you should really put more thought into why your post went negative
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Ok? But like… I don’t know how to say this without sounding harsh, but why would I care that you scoffed when you read the headline?
You were expressing your feelings, but that’s all your first post did. Hell, it’s not immediately clear exactly what you disagreed with. Is the science bad? Is the site untrustworthy? Is the article bad? Or is the only problem that the headline is clickbait?
At least if you said “this headline is bullshit”, someone could have either agreed and moved the conversation towards what the headline should have said, or they’d say “no, it sounds crazy but this is actually legit”
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It is certainly early, they have not even tested it on animals. Many promising drugs either do not work as believed or have nasty side effects that make them unusable. But we humans have invented many other amazing things. While caution is warranted, just writing it off as impossible is also premature.
More work is needed to study Hubbell’s pGal compounds in humans, but initial phase I safety trials have already been carried out in people with celiac disease, an autoimmune disease that is associated with eating wheat, barley, and rye, and phase I safety trials are underway in multiple sclerosis.
This is extremely promising. If this “reverse vaccine” is brought to market and holds up in effectiveness, it could usher in a new era of health, this could spell the end of autoimmune disorders, allergies, and other negative immune responses.
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